Tuesday, July 25, 2017

Cuba found a cancer vaccine! More than 4 thousand people have already been cured by it!



The most deadly disease of our time is for sure the cancer and scientists still can not find a cure about it.Lots of the scientists spend their life searching and studying about the cure of cancer and until they find it they have come up with a radiation and chemotherapy cure.
The latest example is a research from Cuba, where a small group of scientists with a limited budget have been able to develop a vaccine against cancer that has cured more than 4000 people! The scientific community is impressed by the Cuban discovery, and many doctors claim that the cure for cancer has finally been found!
The vaccine has produced incredible results even in the more advanced stages of cancer. It finally saw the light of day after 16 years of intense research, and doesn’t have any adverse side-effects. What’s even more impressive is the fact that a country like Cuba has managed to develop such a marvelous creation instead of bigger countries and pharmaceutical giants that were not even close.
The vaccine works by attacking a protein known as EGF (epidermal growth factor), which allows lung cancer cells to grow. The CIMAvax vaccine reinforce the immune system and accelerates the production of antibodies that bind to EGF, preventing it to feed cancer cells and not allowing the disease to spread. This improves the longevity of the patient and effectively stops the disease from progressing. The administration of the vaccine also relieves the symptoms of cancer and reduces the pain – after a few therapies, patients have seen a significant weight gain and got their appetite and energy back. The vaccine has already arrived in countries such as Bosnia & Herzegovina, Paraguay, Colombia and Peru.
There are high hopes among Cuban scientists that the vaccine can cure breast, uterus and prostate tumors, while further research on other types of cancer is underway. The vaccine is free for Cubans, while people from other parts of the world may inform themselves on the vaccine by contacting the Cuban medical services:
HOW TO GET THE VACCINE AND HOW CAN YOU CONTACT EXPERTS FROM CUBA?!
EscoZul is produced only in the Cuban company Labiofam: AvenidaIndependencia km. 16 1/2 Boyeros, Santiago de las Vegas, Havana, Cuba Tel: +53 683 3188/683 2151, fax: 683 2151, tel. 537 683 2151 Phone Dr. Verges – radiologist and Niudis Cruz: 537 683 0924, e> mail: niudis.cruz@infomed.sld.cu and labiofam@ceniai.inf.cu.
THE NATIONAL CENTER FOR HEALTH HAS THE FOLLOWING CONTACTS:
Director — Dr. Jose Andres Lopez Losada, [email protected] Number is +5378322202, and “Health Tourism”: Calle 230 entre 15A and 17, Siboney, Havana, Cuba, tel. +53 7 33-7473 al 74 Fax: +53 7 33-7198 y +53 7 33 -7199, email: [email protected]
Web: Centro Internacional de Salud La Pradera
ANOTHER USEFUL CONTACT IS THE NATIONAL INSTITUTE OF ONCOLOGY.
They perform many studies, develop drug treatments: InstitutoNacional de Oncología y Radiobiología — INOR, address: Calle 29, esq. F, Vedado, Plaza de la Revolución, Havana, Cuba,
tel. (537) 8325865, (537) 8382576, (537) 8382578, (537) 8375440. Fax (537) 8382593,
Website www.inor.sld.cu
We really hope you find this article helpful and don’t forget to share it with your friends and family. Thank You.

HOW TO REMOVE GOUT & JOINT PAIN FROM YOUR LIFE (URIC ACID & CRYSTALS)

A quick look at the average western diet presents an obvious truth when it comes to the state of wellness in the west; for the most part, we are eating ourselves sick.
Interestingly, how we combat the reality of our sick state is often disconnected from the reasons why we got sick in the first place; our diets. What if doctors prescribed dietary changes first before even looking at medication, especially if it’s not needed? What if food was seen as a mechanism to prevent illness? I believe there is a growing body of people looking at our diets in this manner, but for the most part we’re blind to the fact that our diet is likely one of the biggest contributors to why we are sick.
Of course emotions and our state of being is another huge factor, but let’s start here for now.
A recent study found that a diet rich in acidic foods increases uric acid levels in the body, leading to conditions such as gout (form of arthritis), joint pain, and uric acid crystallization.
What you might notice here is that the average western diet is very acidic, so is it any surprise that so many struggle with these conditions?
Peter was suddenly jolted from his sleep by a sharp and throbbing pain in his left foot. He looked down to see that his big toe was extremely swollen and red, so tender and sore that even the lightest friction from the bed sheet was too much to bear. This was becoming a common occurrence in his life, a highly inconvenient one at that.
Wendy could barely function at work. She struggled to even finish her morning coffee for fear of having to go to the bathroom, for every time she did, she would nearly pass out from the immense pain shooting through her belly and pubic area. This was her second case of kidney stones in the same year.
If you or somebody you know is suffering from kidney issues, joint pain, or a condition known as gout, then you probably know how unfortunate it is to experience a lower quality of life at the hands of a debilitating ailment.Uric acid crystallization has been linked to gout, kidney stones, joint pain, and more.
According to Global RPH, approximately 2 million people suffer from gout, a form or arthritis, 75-90% of which are men. Gout has been known to lead to painful conditions such as kidney stones due to the build up of uric acid in the blood or urine.
Although there are multiple factors which can lead to high levels of uric acid in the body, a recent study suggests that uric acid build-up can be linked to one substantial factor – an acidic diet. The study explores the theory that by introducing a more alkaline diet to the body, one can effectively lower uric acid levels, thereby reducing instances of gout and other kidney and joint related issues.

What The Scientific Evidence States

The study enrolled a group of healthy female students, who had no medical problems at their regular physical examinations provided by the university, in a back-to-back 5-day study which compared urine samples from a high-protein, less vegetable/fruit laden diet (acidic) to a low-protein, high-vegetable/fruit diet (alkaline).
Researchers measured the total volume of urine, the pH, levels of organic acids, creatinine, uric acid, and titratable acid, as well as all cations (Na+,K+,Ca2+,Mg2+,NH4+) and anions (Cl,SO42−,PO4) necessary for the estimation of acid–base balance.
The study noted a linear relationship between higher acidic serum levels and the metabolic degradation of materials being consumed (diet).  Uric acid in the serum was higher in the acidic group than in the alkaline group, therefore from these observations, it is considered that uric acid may be reabsorbed more actively in acidic urine than in alkaline urinewhere it is more actively excreted.

Conclusion & What To Eat For Alkalinity

According to the study, high protein foods (rich in amino acids) were prone to acidic by-products. This included meat, eggs, and some dairy products such as butter. Furthermore, foods such as corn, alcohol, sugarsalad oils, and mayo were also found to produce acidic by-products in the body.
On the flip side, here are the foods that produced alkaline conditions in the body:  Green leafy vegetables, pumpkin, miso, basil, cucumber, cabbage, kiwi, pineapple, mushrooms, yams, vinegar, walnuts, bell peppers, and more. (For more info, see appendix)
Researchers also noted that since the study was conducted exclusively on female students, experiments of the same kind need to be performed on male students, on older populations and also on people with hyperuricemia at baseline for generalization of dietary intervention.
Bottom lineDietary intervention is one of the best choices in preventing conditions caused by uric acid build-up such as gout and joint pain, and an alkaline rich diet is an effective way to go about preventing these types of disorders.

The Ultimate Alkalizing Cocktails

Using the acidic/alkaline chart from Alkalife, we’ve put together two fantastic alkalizing cocktails to help eliminate acidic environments in the body. Enjoy!

Ginger-Fruit Iced Tea

Ingredients:
  • Organic ginger tea
  • Purified water
  • 1-2 tablespoons of fresh lemon &/or lime juice
  • 1/4 cup of organic grapefruit juice
Directions:
  1. Steep the ginger tea in purified, alkaline water for 5 minutes or until desired colour. Let cool.
  2. Stir in lemon and/or lime juice as well as the grapefruit juice. Add ice and enjoy! (Can be enjoyed hot as well during the winter months)

The Very-Berry-Banana Smoothie

Ingredients (serves 1):
  • 2 ripe medium-large bananas
  • 2 cups of frozen mixed berries (strawberry, blackberry, blueberry, and/or raspberry)
  • 1-2 cups of kale (spine removed; your choice of variety)
  • 2-3 tablespoons of raw pumpkin seeds
  • 1/2 cup – 1 cup of purified water.
Directions:
  1. Throw all ingredients into a medium-high powered blender until smooth consistency (I used a Vitamix; a Nutribullet also works well).

Wednesday, July 19, 2017

13 Facts About Cancer You May Not Know



Most people consider themselves well-informed about cancer and know cancer facts such as… Smoking puts you at higher risk for lung cancer. Breast cancer can run in families. Excessive alcohol consumption raises the risk of cancer of the liver.
Then there are lesser-known facts about cancer that you might not be aware of. Many of these are surprising and some are downright scary. Education is key to protecting yourself and your loved ones from preventable causes of cancer.

Do You Know these 13 Facts About Cancer?

1. For men living in the United States, there is a 50% risk of developing cancer at some point in their lives. Risk factors are calculated from many criteria including family history of cancer, living environment, age, and habits including smoking and how they eat.
2. Over 28 million people worldwide have already survived cancer. For men, the highest survival rates are from treatment for prostate, colorectal, and melanoma cancers. For women, the highest survival rates are from breast, uterine, and colorectal cancers.
3. A compound derived from marijuana prevents cancer cells from spreading by forcing them to freeze. Cannabis compounds have been studied and found to be effective in stopping cancer metastasis in some aggressive cancers. Cannibadiol, a non-toxic derivative, effectively turned off the gene known to cause cancer to spread.
4. Cigarette smoke contains over 7,000 chemical compounds and 70 of these are known carcinogens. Contained in a single cigarette are thousands of toxic chemicals like lead, tar, and arsenic. Some more familiar chemicals are acetone (nail polish remover), formaldehyde (embalming fluid), and even methanol (rocket fuel).
5. Fluoride promotes cancer. Research indicates a close connection between fluoride and an increased cancer risk. Fluoride has been linked to an increase in oral, bone, liver, thyroid, and other cancers. As it turns out, fluoride turns normal cells into cancer cells, increases tumor growth rate, and also increases cancer death rates.
6. Chemotherapy enriches and induces cancer stem cells. According to a 2015 study published in the American Journal of Cancer Research, and a 2009 Chinese study published in Bioscience Hypotheses, due to the imbalance of angiogenesis and insufficient blood supply in certain regions of the cancer tumor mass, chemotherapy actually transforms the bulk cancer cells to stem cells rather than kill them!
7. Tall women are more prone to getting cancer. Being tall doesn’t mean a woman is going to get cancer. But studies have found a correlation between above average height and an increased chance of developing cancer. Height may be one of the many factors that put a person at risk, and research shows it may be due to an increase in the growth hormone factor, known as insulin-like growth factor-1, or IGF-1.
8. At least three of the original “Marlboro Men” died from lung cancer. The Marlboro Man was an advertising gimmick to encourage more men to smoke the Philip Morris brand. Originally marketed to women, they wanted to aim their campaigns to men and the macho Marlboro Man was born. Before his death, one of the cowboys became an anti-smoking advocate, blaming Philip Morris for his habit. Though smoking ads are now banned in the United States, the Marlboro Man is still an advertising icon in Japan.
9. Prediabetes increases the chance of developing cancer by 15%. People diagnosed with prediabetes (with higher blood glucose levels not yet developed into diabetes) are at higher risk for developing cancer. Studies show that these people are most at risk for endometrial, stomach, liver, pancreatic, breast, and colorectal cancers.
10. Red wine prevents cancer. The resveratrol found in red wine can destroy damaged cells within the body and prevent them from becoming cancerous. It’s a fine line, however, because excess consumption of alcohol is also a cancer risk factor − especially for cancer of the head and neck.
11. Specially trained dogs can sniff out prostate cancer with 98% accuracy.It’s common knowledge that dogs possess powerful noses. Canines have been trained to track scents and find cadavers, but are now being used to detect cancer. In a prostate cancer study with 600 subjects, dogs correctly identified 98% of the positive cases. Federal Food and Drug Administration (FDA) approval is pending for the use of canine medical scent kits but questions remain about the use of dogs “in a clinical setting.”
12. Redheads are the most likely candidates for developing melanoma.People born with red hair typically also have very fair skin and freckles. Scientists have identified this as a genetic mutation. This mutation triggers another known genetic mutation and is believed to be the reason behind the higher rates of redheads developing the most deadly of skin cancers.
13. Airline pilots and flight attendants are more prone to developing skin cancer. Studies show pilots and flight attendants have a higher occurrence of melanoma. Percentages vary with a 10 times higher rate amongst all pilots and up to 25 times higher for pilots that flew regularly over five or more time zones. The cause is likely the combination of higher exposure to radiation and UV rays at flying altitudes and a disruption of the body’s circadian rhythms or sleep patterns.
Identify your personal risks and know the cancer facts. Preventing cancer, fighting cancer, and beating cancer starts with you!
Eating healthy, getting quality sleep, exercising regularly, and ensuring adequate hydration are essential to health and will lower your risk for many diseases. Cutting out bad habits and forming new, healthy habits is the key to enjoying the rest of your life on your own terms. Learn all the facts about cancer you can and then make the changes necessary to keep your body cancer-free.
Want to stay abreast of new ways to stay healthy? Be notified each week when cutting-edge articles are added by clicking here. You’ll be glad you did.

Graviola: A Systematic Review on Its Anticancer Properties



Abstract

There has been an enormous interest in the literature that phyto-compounds have therapeutic and beneficial effects in various diseases including inflammatory associated arthritis, diabetes, hypertension, parasitic infections, and cancer. The leaves from the tropical tree Annona Muricata, also known as Graviola have been reported to have positive and effective properties against many of the above mentioned diseases. Cancer still remains the number one killer in the Western nations and most treatments for the disease rely on the use of chemotherapy that utilizes drugs that are also toxic against normal healthy cells. Thus, an alternative approach to anti-cancer therapies should involve the determination of novel drug targets that must be highly effective and specific against cancer development and growth. Additionally, the new generation novel drugs should be non-toxic to the host cells and affordable for the patients. This review summarizes the recent findings on the effects of Graviola tree extract as a novel anti-cancer agent for the treatment and prevention of cancers; a possible natural anti-cancer candidate agent in line with all the attributes pointed above.

Cite this article:

  • Ioannis, Patrikios, Stephanou Anastasis, and Yiallouris Andreas. "Graviola: A Systematic Review on Its Anticancer Properties." American Journal of Cancer Prevention 3.6 (2015): 128-131.

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At a glance: Figures


1. Natural Extracts against Cancer

Natural Plant extracts have been used for centuries by many cultures and civilizations as a basis for treating various diseases. More than 80% of the global population now depends on natural plant extracts through traditional therapies. [123] Recent investigators have focused on the progression, treatment and prevention of cancer with such compounds but room for improvement still remains.
To date, the use of conventional synthetic chemotherapeutic drugs lack the properties to be considered as effective therapeutic agents, with most of those associated with severe side effects and toxicity of the normal host cells. Whereas an alternative therapeutic approach that uses natural plant extracts is advantageous vs conventional therapy with limited side effects.
One of the first systematic approaches was carried out in 1950 with the vinca alkaloids (vinblastin and vincristine) discovery, isolated from the Catharanthus roseus G. Don. (Apocynaceae) followed by a number of effective extracts such as Triptolide (Tripterigium wilfordii), Amygdalin (B12), Achyranthes aspera Linn. (Family-Amaranthaceae) etc [456].

2. Graviola History

Graviola belongs to Annonaceae family, Annona genus and muricata species. Graviola is a fruit tree with many uses in traditional and alternative medicine. Graviola, soursop, guanábana, guanábano, guanavana, guanaba, corossol épineux, huanaba, toge-banreisi, durian benggala, nangka blanda, cachiman épineux are altering names for this evergreen plant that is mostly distributed in tropical and subtropical regions of the world. Graviola is a heart shaped edible fruit and together with its leaves, root and seeds is known to have beneficial properties in alternative medicine [7].
The fruits of Graviola are extensively used to make candies, syrups, ice creams, shakes and beverages. A wide range of ethno-medicinal activities in Africa and South America extensively use this plant in their conventional medicine. A number of laboratories have reported Graviola’s for its benifical actions against anticonvulsant, antiparasitic, anti-arthritic, antimalarial, antidiabetic hepatoprotective and andicancer activities. Biological and chemical characterization studies indicate that annonaceous acetogenins are the main ingredients of Graviola [8910].
Nowadays more than 100 annonaceous acetogenins that are generally characterized as a family of natural products with antitumor activities, from roots, leaves, barks, fruits and seeds of Graviola have been widely used in alternative medicine for many purposes. In the Peruvian Andes for example, the Graviola leaves are used to combat parasites and treat diabetes. In the Brazilian Amazon the leaves were used to treat liver problems and the leave – extracted oil is believed to help with rheumatism, neuralgia and arthritis. In the Eastern Andes and Jamaica, Haiti the juice of Graviola was used to stop diarrhea, used as muscle relaxant and lower the intestinal acidity [11-15][11].
Other reports have demonstrated that Graviola has a number of biological activities such as antifungal, anti-bacterial, anti-malarial and antioxidant. Furthermore, it has been showed to have anti-cancer properties on multi-drug resistant cancer cell lines. [1617181920] The ability of Graviola to have selective growth inhibition against a variety of cancer cells including lung carcinoma cell lines, breast solid tumor lines, prostate adenocarcinoma, pancreatic carcinoma cell lines, colon adenocarcinoma cell lines, liver cancer cell lines, human lymphoma cell lines, and multi-drug resistant human breast adenocarcinoma will be discussed based on previously published data [212223242526].
2.1. Composition
Graviolas fruit flesh consists of 80% water, 1% protein, 18% carbohydrates and small amount of vitamins B, B2, C, potassium and dietary fiber. [2728] The main group, annonaceous acetogenin, is a unique set of derivatives of C35 or C37 long chain fatty acids derived from the polyketide pathway (Figure 1). The annonaceous acetogenins found in Graviola include Annocatalin, annohexocin, annomonicin, annomontacin, annomuricatin A & B, annomuricin A thruE, annomutacin, annonacin, annonacinone, annopentocin A thru C, cis-annonacin, cis-corossolone,cohibin A thru D, corepoxylone, coronin, corossolin, corossolone, donhexocin, epomuricenin A & B,gigantetrocin, gigantetrocin A & B, gigantetrocinone, gigantetronenin, goniothalamicin, iso-annonacin, javoricin, montanacin, montecristin, muracin A thru G, muricapentocin, muricatalicin,muricatalin, muri-catenol, uricatetrocin A & B muricatin D, muricatocin A thru C muricin H,muricin I, muricoreacin, murihexocin 3, murihexocin A thru C, murihexol, murisolin, robustocin, rolliniastatin 1 & 2, saba-delin, solamin, uvariamicin I & IV, xylomaticin isolated from the leaves, root and stem barks of Graviola [293031].


Figure 1.Bullatacin chemical structure, one out of the three main annonaceous acetogenin molecules including asimicin and bullatalicin that it is believed to be the one most bio-active anti-cancer molecule found in the Graviola extract
The essential oil of the fresh fruit pulp contains 2-hexenoic acid methyl ester (23.9%), 2-hexenoic acid ethyl ester (8.6%), 2-octenoic acid methyl ester (5.4%), 2-butenoic acid methyl ester (2.4%), β-caryophyllene (12.7%), 1,8- cineole (9.9%), linalool (7.8%), α-terpineol (2.8%), lialyl propionate (2.2%) and calarence (2.2%) [32].
Limited number of published data are found in literature for the anti-carcinogenic potential of Graviola natural extracts. Recent studies have suggested that Graviola also expresses analgestic and anti-inflammatory effects, promotes apoptosis (programmed cell death) and cytotoxicity on cancer cells that may result from the presence of alkaloids, essential oils and acetogenins. [11333435] These acetogenins demonstrated to be selective and toxic against various types of cancer cells without harming normal and healthy host cells [363738].
2.2. Anticancer Characteristics
It has been previously reported that the Graviola extracts have significant anti-cancer effects in a number of cancer cell lines both in vitro and in vivo. [39] Studies revealed the Graviola extracts as having selective inhibition of breast cancer cells via EGFR downregulation. The epidermal growth factor receptor (EGFR) is an oncogene frequently overexpressed in breast cancer (BC), and its overexpression has been associated with poor prognosis and drug resistance. EGFR is therefore a rational target for BC therapy development. In addition, experiments showed that Graviola fruit extract (GFE) inhibit the growth of BC cells using xenografts mouse model studies. Moreover, GFE selectively inhibited the growth of EGFR-overexpressing human BC (MDA-MB-468) cells but not in non-tumorigenic human breast epithelial cells (MCF-10A). [39] These studies strengthen the evidence that Graviola has selective anti-growth effects between cancer and non-cancer cells.
Another study on breast cancer cells supported that Graviola promotes apoptosis in ER-related pathways. Moreover, Graviola decreased MCF-7 tumor growth while inhibiting ER-cyclin D1 and Bcl-2 protein expressions in nude mice. [40] In colon cancer cells, Graviola leaves also has significant effects on cell survival potential via mitochondrial-mediated apoptosis associated with the G1 cell cycle arrest. Graviola induces apoptosis by generating reactive oxygen species ROS and down-regulating the anti-apoptotic Bcl-2 protein, while up-regulating pro-apoptotic Bax protein. These processes subsequently lead to attenuation of mitochondrial membrane potential (MMP) and cytochrome c release. Release of cytochrome c activates apotosome and the intrinsic caspase cascade that triggers execution of apoptosis through DNA fragmentation. [41] Graviola has also been reported to have anti-proliferative effects of HL-60 cells via loss of cell viability, loss of MMP, G0/G1 phase cell arrest and morphological apoptotic changes. These results substantiate and confirm that Graviola does indeed have anti-proliferative and cytostatic activity in HL-60 cells [42].
In Vitro and in vivo model studies demonstrated the effect of Graviola extract in prostate cancer cell lines. These experiments showed that Graviola promotes necrosis in PC-3 cells through inhibition of tumor mobility and cellular metabolism. Further studies demonstrated downregulation of the expression of the hypoxia-related factors and glycolytic factors following treatment in PC cells with Graviola (i.e. HIF-1α, NF-κB, GLUT1, GLUT4, HKII, and LDHA) [26].
Follow up studies reported the in vivo Graviola leaf extract (GLE) pharmacokinetics and in vitroabsorption kinetics resulting in inhibiting in vitro prostate cancer proliferation, viability and clonogenic colonies. Oral administration of 100mg/kg bw GLE showed tumor growth-inhibition in human prostate tumor in xenografts studies. This study also demonstrated the synergy among the constituents of Graviola leaf extract (GLE) compared to its flavonoid-enriched (FEF) and acetogenin-enriched (AEF) fractions [4354].
In another study Graviola also had effects on Lewis lung carcinoma (LLC) tumor cell lines that were examined both in vivo as well as in vitro. The study suggested that Graviola once again had antitumor activity by inhibiting the normal growth of the lung tumors. [47] Further studies also indicated the anti-cancerous and cytotoxic mechanisms of action of Graviola that affected NADH oxidase inhibition in cancer cell lines, downregulation of the P-glycoprotein pump via ATP depletion and Cell cycle arrest at S-phase progression [48495051].
A recently published study demonstrated also the preventive measure against 7,12-dimethylbenzeneanthracene DMBA-induced breast cell proliferation in the breast tissues of female albino mice. Once again, the study supported that the Graviola leaf extract could act as a cancer prevention agent [52].

3. Concluding Remarks

Overall, this mini review lists the existing knowledge about the natural plant extract agent, Graviola, and gives an insight on the important in vitro and in vivo studies that have been carried out based on its efficacy and functional characteristics. However, further studies are required to verify the exact properties and the mechanisms of action. Even though several reports demonstrated positive actions of Graviola, more robust and systematic clinical trials to test and verify its true validity and safety are necessary, in order to be confirmed as a therapeutic anti-cancer agent. Thus, well-designed, randomized, double blind trials are of major importance.
Concluding, the present review demonstrates the advantages of the possible use of Graviola for cancer treatment. Existing conventional cancer therapies are known to be highly toxic with severe side-effects that affect the quality of life of the patients and with no more than 6 months contribution of life expectancy [5657]. Therefore, new drugs need to be developed that include bioactive natural molecules such as Graviola that do not have toxic side-effects and are selective in killing cancer cells but not the normal/physiological healthy host cells. Furthermore, pro-inflammatory responses and pathways are activated and suggested to play an important, primary role in tumourgenesis. Graviola with known strong anti-inflammatory effects can warrant a new in vivo study to determine whether one mechanism of action, could possibly be, through specifically inhibiting the site of inflammation in solid cancers [53,55].

Table 1. Scientific findings of previously published work on Graviola


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